Post Date December, 03 2023
It seems that nephrotic syndrome is not a very serious situation, and it is relatively normal for nephrotic patients to experience nephrotic syndrome. So some patients may overlook treatment. In fact, the treatment of nephrotic syndrome should be timely, and the consequences of not treating it can be quite serious. These are common consequences.
Patients with kidney disease have a relatively low immune system and their renal function can be affected, making them prone to infection. Due to the loss of a large amount of immunoglobulin from urine, plasma proteins decrease, which affects the formation of antibodies. The application of adrenocortical hormones and cytotoxic drugs reduces the patient's overall resistance, making it highly susceptible to infections, such as skin infections, primary peritonitis, respiratory infections, urinary tract infections, and even severe lesions such as sepsis. Coronary heart disease: Patients with nephrotic syndrome often have hyperlipidemia and hypercoagulability, making them prone to coronary heart disease. Some people have reported that the incidence of myocardial infarction in patients with nephrotic syndrome is 8 times higher than in normal individuals. Coronary heart disease has become the third cause of death in nephrotic syndrome (second only to infection and renal failure).
Nephrotic syndrome can also have an impact on the patient's blood flow, for example, it is more likely to lead to thrombosis: especially, the incidence of membranous nephropathy can reach 25% to 40%. The causes of thrombosis include edema, low patient activity, venous stasis, hyperlipidemia, increased viscosity due to blood concentration, high fibrinogen content, and increased levels of factors v, VII, VIII, and X, as well as the use of adrenal cortical hormones, which can easily lead to hypercoagulable blood. Patients with nephrotic syndrome often experience low blood volume and hypercoagulability due to excessive proteinuria, hypoproteinemia, and hyperlipidemia. When vomiting, diarrhea, and the use of antihypertensive drugs and diuretics for diuresis can cause a sudden decrease in renal blood perfusion, leading to a decrease in glomerular filtration rate and acute renal failure. In addition, acute renal failure can also be induced by factors such as renal interstitial edema and protein concentration forming tubular blockages in nephrotic syndrome.
It can be seen that if patients neglect nephrotic syndrome, it is likely to lead to some very serious consequences. Especially, it can cause phenomena such as kidney failure, endangering the patient's life. So patients should start prevention from their daily routine and not wait until their condition becomes severe before receiving treatment.
