1. Hormone therapy
Prednisone is commonly used, and according to the type of disease and the patient's response to prednisone, a short course of 8 weeks, a medium course of 4-6 months, and a long course of 9-12 months are used. Short courses are used for primary treatment of simple kidney disease, while medium and long courses are used for recurrent or inflammatory kidney disease.
Efficacy evaluation: ① Hormone sensitivity: Urinary protein turns negative and edema subsides within 8 weeks after hormone treatment. ② Hormone sensitivity: Edema subsides within 8 weeks of treatment, but urinary protein remains at 10 to 10%. ③ Hormone resistance remains at least 10% after 8 weeks of treatment; ④ Hormone dependence: Those who turn negative in urine protein after hormone treatment, but show "+" or more after stopping or reducing dosage, and turn negative in urine protein twice or more after re medication or resuming dosage (excluding infection and other factors). The above urine changes refer to the results of three routine urine tests distributed within 7-10 days.
2. Immunosuppressants
Cases with poor hormone therapy or significant side effects can be treated with a combination of immunosuppressive agents, commonly used including vincristine, Tripterygium wilfordii glycosides, cyclophosphamide, and thiazole; Cyclosporin A, etc.
3. Diuretics
Generally, cases sensitive to hormone therapy may experience diuresis after 7-10 days of medication, and there is no need to use diuretics. Diuretics can be used in case of severe edema. Furosemide (furosemide) is usually used for intravenous administration. It is better to infuse low molecular dextran first, which can often produce good diuretic effect.