Because there is a lipid membrane on the surface of the prostate gland, most antibiotics are difficult to enter the prostate through this membrane to play a therapeutic role, so the following principles should be followed when selecting antibacterial drugs:
(1) The drug has high sensitivity to bacteria.
(2) Drugs with high liposolubility, high permeability, low binding rate with plasma protein and high dissociation degree should be taken as the standard for determining the drugs to be used.
(3) The combination of two or more drugs with synergistic effect.
(4) In order to achieve the effective concentration of drugs in the prostatic stroma and prevent the occurrence of urethral infection, the drug use method with super-dose and time-limit (4~12 weeks) should be advocated.
Main disadvantages of prostate injection:
① The prostate is deep, direct injection is not easy, puncture can cause damage to surrounding tissues and cause hematuria;
② Puncture can cause pain and discomfort, which is difficult to be accepted by patients if repeated;
③ Transdermal or transrectal puncture can bring bacteria into the prostate, causing repeated infection of the prostate;
④ Repeated puncture can cause hyperplasia of prostate fibrous tissue and prostate sclerosis. During anal diagnosis, the prostate can be palpated with induration or a hard prostate. Fibrous tissue hyperplasia will cause the focus to be separated and surrounded, and the antibiotic is more difficult, and it will make the excretion of prostate fluid difficult.
Therefore, it is necessary to be cautious when selecting this treatment method. Only when other methods are ineffective, this method should be considered, and the puncture should not be too frequent. The puncture should be performed 1-2 times a week, and the course of treatment should not be too long. It should be controlled within 1-2 months.